Aspirin has been used as a medicine by the ancient Greeks and the pharaohs of Egypt. It is effective in reducing pain (it is an analgesic), reducing inflammation (anti-inflammatory), reducing fever (antipyretic), and thinning blood (anti-coagulant).
To download a student copy of the lab handout, click the link to the file at the bottom of this page. Laboratory Exercise: Synthesis of A Drug Background: In this lab, you are going to synthesize a very popular and widely used medicinal drug, aspirin (acetylsalicylic acid).
Why is acetic anhydride used in aspirin synthesis? | Socratic
Jan 25, 2018· Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as anti-inflammatory medication. Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. Synthesis of Aspirin is known as esterification.
CHEM 1211 Lab-Synthesis of Aspirin Introduction: Aspirin is probably the most recognizable analgesic (pain reliever) in use today. It was first synthesized in 1893 at the Bayer Chemical Company in Germany from salicylic acid. Salicylic acid was first
Jan 25, 2018· Synthesis of Aspirin By: Jon Torre Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2). Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water.
Lab: Synthesis of Aspirin. Aspirin is synthesized by an esterification reaction, which occurs when an alcohol reacts with a carboxylic acid to form an ester. To synthesize aspirin, you will be reacting salicylic acid (which contains the alcohol) with acetic anhydride (which will function as the acid, acetic acid,.
Dec 15, 2011· Part of NCSSM CORE collection: This video shows the synthesis of aspirin. .dlt.ncssm.edu Please attribute this work as being created by the North C.
aspirin product as well as a commercial aspirin tablet will be compared to a standard 0.15% ferric-salicylate solution. In the presence of moisture, aspirin may decompose (hydrolysis) into salicylic acid and acetic acid. This reaction is the reverse of the synthesis reaction. The maximum allowable amount of
Synthesis and Analysis of Acetyl Salicylic Acid Amy Chan CHEM 290 - Section 1 November 25, 2002 . Chan 1 . Synthesis of Aspirin In the first part of the experiment, aspirin was synthesized. . carried back to the lab bench. At the lab bench, the aspirin crystallized out of the solution. Crystallization was induced by scratching the
Aspirin Synthesis and Analysis Revised: 12/13/14 • Crush an aspirin tablet and place in a labeled, pre-weighed vial or test tube. Record the mass of the aspirin tablet. Do not lose this container or its contents, you will use them later. • Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate.
Considerations when Seeking Synthesis of Aspirin Lab Report Writing Help. It is increasingly becoming apparent to students and instructors that the quality of scientific writing is just as significant as experimenting or investigating.
Synthesis of aspirin from salicylic acid using acetic anhydride BACKGROUND. Principle: Synthesis of aspirin from salicylic acid occurs by acetylation process in. REQUIREMENTS. Acetic anhydride – 8.5 ml . PROCEDURE. Weigh 6 gs of salicylic acid and transfer it to a clean and dry 250 ml conical .
An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. It is the two-step synthesis of aspirin starting from oil of wintergreen. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer.
After synthesis and analysis, it will be deter-mined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both (3). Figure 1: Reaction of Aspirin (Snelling, 2013) MATERIALS AND METHODS Goggles Gloves Lab coat Salicylic Acid 50 mL Erlenmeyer Flask
82 EXPERIMENT 5: SYNTHESIS OF ASPIRIN • Report data collected and subsequent calculations to em21labs. • All equipment should be returned to the correct location after use. WASTE • Salicylic acid should be disposed of in the solid waste container.
aspirin is shown in Figure 1. COOH OH Salicylic Acid COOH O C O CH3 Acetylsalicylic Acid (Aspirin) Fig. 1: Aspirin vs. Salicylic Acid The first person to do so was a French chemist named Charles Frederic Gerhardt. In 1853, Gerhardt neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride, creating acetylsalicylic acid.
Pre-lab exercise Preparation of Aspirin (Complete and check answers before coming to lab) 1. During the preparing aspirin lab activity, a student attempts to determine how much aspirin she made. She looked back at her data: mass of flask 73.86 g _ mass of flask and salicylic acid 77.88 g __
Jul 18, 2016· Synthesis of Aspirin Lab. Add as much of the NaOH as the Aspirin solution first acquired (15mL). Heat the solution in warm bath for 10 minutes. Back titrate the solution using 0.1M of HCl. When the solution turned color, test for the accuracy by adding drops …
-In the synthesis of aspirin, you will treat salicylic acid with acetic anhydride-In order to proceed, the reaction requires an acid catalyst - phosphoric acid -In this lab, we will be using 90% of our salicylic acid to synthesize aspirin
Mar 03, 2014· Essay on Synthesis of Aspirin 5275 Words | 22 Pages. The Synthesis of Aspirin Chemistry Standard Level Lab Report Data Collection and Processing and Conclusion and Evaluation Date: December 8th, 2011 Purpose: The purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by …
SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. H 2 SO 4 (use a dropper, H 2 SO 4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.; Heat the flask gently on the steam bath for at least 10 minutes.
BACKGROUND. Principle: Synthesis of aspirin from salicylic acid occurs by acetylation process in acidic medium. Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.
Aspirin Synthesis Lab Part 1: The Synthesis of Aspirin Procedure Steps 3 - 5 were repeated twice more for two more titrations. Part 3: Preparation and Standardization of HCl Procedure Part 4: Quantitative Analysis of Aspirin Further Analysis Conclusion The overall objectives of
Washing the aspirin removed most of the unreacted salicylic acid and acetic anhydride to yield a purer product. Some product was dissolved and lost in the washing process. Cold water was used to minimize dissolving the product. How did the synthesis use different temperatures to affect the solubility of aspirin?
Aug 28, 2016· Aspirin is prepared from salicylic acid. Applications and skills: Explanation of the synthesis of aspirin from salicylic acid, including yield, purity by recrystallization and characterization .
CHEM 322: Synthesis of Aspirin Introduction: Aspirin is one of the milder and least expensive pain relievers available. Today, Americans spend about $2 billion a year for non-prescription pain relievers. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. Unlike many other formulations, the
aspirin to diminish inflammation is due to its inhibition of the synthesis of prostaglandins. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. Though aspirin has numerous benefits, there are several adverse affects as well. It is
Los Angeles City College Chemistry 51 Fall 2005 3093 1 Experiment 11 Synthesis and Analysis of Aspirin INTRODUCTION Aspirin is most widely sold over-the-counter drug. It has the ability to reduce fever (an antipyretic), to