In this experiment, aspirin will be synthesized by reacting acetic anhydride with salicylic acid in the presence of phosphoric acid. The reaction equation is displayed below. After synthesis, the sample will be purified by recrystallization meth-ods. The purity of the sample will then be ana-lyzed using TLC. The results section will present
Experiment 11 Synthesis and Analysis of Aspirin INTRODUCTION Aspirin is most widely sold over-the-counter drug. It has the ability to reduce fever (an antipyretic), to reduce pain (an analgesic), and to reduce swelling, soreness, and redness (an anti-inflammatory agent). One of
salicylate solution. In the presence of moisture, aspirin may decompose (hydrolysis) into salicylic acid and acetic acid. This reaction is the reverse of the synthesis reaction. The maximum allowable amount of free salicylic acid in an aspirin sample is 0.15% salicylic acid. Equipment and Reagents First Period
It is the two-step synthesis of aspirin starting from oil of wintergreen. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer.
Dec 15, 2011· Part of NCSSM CORE collection: This video shows the synthesis of aspirin. .dlt.ncssm.edu Please attribute this work as being created by the North C.
Synthesis and Characterization of Aspirin. Reaction of Salicylic Acid and Acetic Anhydride to form Aspirin and Acetic Acid The rings shown in the Salicylic acid and Aspirin molecules are hexagonal rings of carbon compounds, with alternating single and double bonds as indicated by the double lines.
SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. H 2 SO 4 ( use a dropper, H 2 SO 4 is highly corrosive ) and swirl the flask gently until the salicylic acid dissolves.